Regulatory History: Cyclamate
Tracking global safety evaluations, classification changes, and regional status updates for E952.
Factual Regulatory Reference
This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and is subject to change. Always refer to your local regulatory authority for the most current information.
Comprehensive Timeline
Cyclamate discovered accidentally by graduate student Michael Sveda at University of Illinois.
FDA approved cyclamate as GRAS (Generally Recognized As Safe) sweetener.
Studies suggested that cyclamate combined with saccharin may cause bladder cancer in laboratory rats.
FDA banned cyclamate in the USA under Delaney Clause due to cancer concerns in animal studies.
JECFA established ADI of 0-11 mg/kg bw/day, concluded cyclamate is safe at this level.
Cyclamate approved as E952 in the EU with maximum use levels specified.
Scientific Committee on Food re-evaluated cyclamate, confirmed ADI of 7 mg/kg bw/day (lower than JECFA).
EFSA re-evaluated cyclamate and cyclamic acid (E952), maintained previous safety conclusions and ADI.
Cyclamate remains banned in USA despite multiple petitions for re-approval and approval in many other countries.