Regulatory History: Titanium Dioxide
Tracking global safety evaluations, classification changes, and regional status updates for E171.
Factual Regulatory Reference
This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and is subject to change. Always refer to your local regulatory authority for the most current information.
Comprehensive Timeline
FDA approved titanium dioxide for use in food, not to exceed 1% of food weight.
Food-grade titanium dioxide authorized in the EU under E171 designation.
EFSA re-evaluated E171, identified data gaps on particle size distribution and possible effects on reproductive system. Recommended new studies.
France suspended use of E171 in food products, ahead of EU-wide action, citing precautionary principle.
EFSA concluded E171 can no longer be considered safe as a food additive. Genotoxicity concerns could not be ruled out after reviewing evidence on nanoparticles.
Commission Regulation (EU) 2022/63 published, removing E171 from permitted additives list (Annexes II and III). Six-month transition period announced.
Full ban on E171 as food additive in EU entered into force.
EU Court of Justice ruling confirmed that titanium dioxide powder forms are no longer classified as suspected carcinogen by inhalation, but food ban remains.