flavor_enhancer INS 635

Disodium 5'-Ribonucleotides E635

nucleotide_umami β€” Primarily natural_or_synthetic.

πŸ‡ͺπŸ‡Ί EU: Approved
πŸ‡ΊπŸ‡Έ USA: Approved
πŸ‡―πŸ‡΅ Japan: Approved
πŸ‡¦πŸ‡Ί AU/NZ: Approved
πŸ‡¨πŸ‡¦ Canada: Approved
Scientific Name

Disodium 5'-ribonucleotides

CAS: 4691-65-0 / 5550-12-9

Data verified: 2026-04-04

Factual Regulatory Reference

This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and is subject to change. Always refer to your local regulatory authority for the most current information.

? Did You Know?

Disodium 5'-Ribonucleotides occurs naturally in Combination found naturally in meat and fish and Mushrooms. Many people consume it daily without realizing it's also a listed food additive.

Disodium 5'-Ribonucleotides is produced through fermentation β€” the same biological process used to make bread, beer, and yogurt.

In the EU, Disodium 5'-Ribonucleotides has a "quantum satis" authorization β€” Latin for "as much as needed." This means there's no specific maximum limit; manufacturers use only what's technologically necessary.

Detailed Regulatory Assessment

πŸ‡ͺπŸ‡Ί

European Union (EFSA)

approved Max: quantum satis mg/kg

None

Official EFSA Link
πŸ‡ΊπŸ‡Έ

United States (FDA)

approved GRAS

Generally recognized as safe

πŸ‡―πŸ‡΅

Japan (MHLW)

approved Cat: ζ—’ε­˜ζ·»εŠ η‰©

Compliant with Japanese food sanitation law.

Acceptable Daily Intake (ADI)

International Standard (JECFA)

Not specified (ADI not limited)

mg/kg body weight per day

European Standard (EFSA)

Not specified

Everyday Perspective

For a 60kg adult, this limit is roughly equivalent to consuming:

Natural Occurrence

A mixture of disodium inosinate (E631) and disodium guanylate (E627), typically in equal proportions. This is the powerhouse umami enhancer found in instant ramen, creating synergistic effects with MSG that multiply umami taste up to 8-fold.

Combination found naturally in meat and fishMushroomsAged and fermented foods

Manufacturing

Method: mixing of purified nucleotides

Produced by blending purified disodium inosinate (E631) and disodium guanylate (E627), each produced by enzymatic degradation of RNA or microbial fermentation.

Frequently Asked Questions

What is Disodium 5'-Ribonucleotides (E635)?
Disodium 5'-Ribonucleotides (E635) is a flavor_enhancer used in food products. It is nucleotide_umami and natural_or_synthetic. A mixture of disodium inosinate (E631) and disodium guanylate (E627), typically in equal proportions. This is the powerhouse umami enhancer found in instant ramen, creating synergistic effects with MSG that multiply umami taste up to 8-fold.
Where is Disodium 5'-Ribonucleotides found naturally?
Disodium 5'-Ribonucleotides is naturally found in Combination found naturally in meat and fish, Mushrooms, Aged and fermented foods. A mixture of disodium inosinate (E631) and disodium guanylate (E627), typically in equal proportions. This is the powerhouse umami enhancer found in instant ramen, creating synergistic effects with MSG that multiply umami taste up to 8-fold.
What is the ADI for Disodium 5'-Ribonucleotides?
The Acceptable Daily Intake (ADI) for Disodium 5'-Ribonucleotides is Not specified (ADI not limited) as established by JECFA (Joint FAO/WHO Expert Committee on Food Additives). ADI represents the amount that can be consumed daily over a lifetime without appreciable health risk.
What foods contain Disodium 5'-Ribonucleotides?
Disodium 5'-Ribonucleotides is used in various food categories including Salts, spices, soups, sauces, salads and protein products. It is used as a flavor_enhancer in these products.
Is Disodium 5'-Ribonucleotides the same as I+G?
Yes, Disodium 5'-Ribonucleotides is also known as I+G, Nucleotide blend, Disodium IMP+GMP. These are different names for the same substance.