Hydroxypropyl Methyl Cellulose E464
emulsifier, stabilizer, film-former, gelling agent, coating agent β Primarily natural (modified).
Hydroxypropylmethylcellulose (HPMC)
CAS: 9004-65-3
Factual Regulatory Reference
This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and is subject to change. Always refer to your local regulatory authority for the most current information.
? Did You Know?
Hydroxypropyl Methyl Cellulose is derived from plant materials β its origin is more natural than its E-number might suggest.
Beyond food, Hydroxypropyl Methyl Cellulose is also used in cosmetics, medicine, industrial applications, household products. Its versatility makes it one of the most multi-purpose chemical compounds in everyday life.
Although classified as natural in origin, commercial Hydroxypropyl Methyl Cellulose is typically manufactured rather than extracted directly from food sources.
Detailed Regulatory Assessment
European Union (EFSA)
Widely permitted in most food categories; considered safe cellulose derivative.
United States (FDA)
Also approved for pharmaceutical use
Japan (MHLW)
Compliant with Japanese food sanitation law.
Acceptable Daily Intake (ADI)
International Standard (JECFA)
mg/kg body weight per day
European Standard (EFSA)
Natural Occurrence
This additive is not known to occur naturally in significant quantities.
Manufacturing
Produced by treating cellulose with alkali, then reacting it with methyl chloride and propylene oxide. This dual substitution gives HPMC a unique combination of properties - it's water-soluble, forms clear gels, and creates flexible films. The ratio of methyl to hydroxypropyl groups can be varied to create different grades.
Applications Beyond Food
Thickener and film-former in shampoos, lotions, and cosmetics.
Vegetarian capsule shells (gelatin alternative), tablet binder and coating, ophthalmic solutions, controlled-release matrix.
Construction (tile adhesive, cement modifier, wallpaper paste), paints, ceramics, textiles.
Tile grout, paint thickener, personal lubricants.