Natamycin E235
natural antimicrobial — Primarily NATURAL (produced by bacteria).
Natamycin (polyene macrolide antibiotic)
CAS: 7681-93-8
Factual Regulatory Reference
This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and is subject to change. Always refer to your local regulatory authority for the most current information.
? Did You Know?
Natamycin occurs naturally in Produced by soil bacterium Streptomyces natalensis. Many people consume it daily without realizing it's also a listed food additive.
Natamycin is produced through fermentation — the same biological process used to make bread, beer, and yogurt.
Natamycin isn't just a food additive — it's also used in medicine.
Detailed Regulatory Assessment
European Union (EFSA)
RESTRICTED to surface treatment of cheese and dried sausages ONLY; not for internal use
Official EFSA LinkUnited States (FDA)
Approved for surface treatment of cheese and dried sausages
Japan (MHLW)
Approved as existing food additive (natural origin)
Acceptable Daily Intake (ADI)
International Standard (JECFA)
mg/kg body weight per day
European Standard (EFSA)
Everyday Perspective
For a 60kg adult, this limit is roughly equivalent to consuming:
Natural Occurrence
NATURAL antifungal produced by soil bacterium Streptomyces natalensis. Named after Natal, South Africa where the bacteria was discovered. Also called 'pimaricin' (from Pietermaritzburg, South Africa). Works ONLY on the surface - not meant to penetrate into food. The white coating you see on some cheese rinds is often natamycin. Extremely effective against yeasts and molds but has NO effect on bacteria. Does NOT promote antibiotic resistance because it's only used on surfaces and breaks down quickly. Used in medicine as antifungal for eye infections (not taken orally).
Manufacturing
Produced by fermentation using Streptomyces natalensis bacteria, then purified and concentrated for use as a surface treatment antifungal.
Applications Beyond Food
Used as antifungal medication for eye infections (ophthalmic use)