Nisin E234
natural antimicrobial — Primarily NATURAL (produced by bacteria).
Nisin (polycyclic antibacterial peptide)
CAS: 1414-45-5
Factual Regulatory Reference
This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and is subject to change. Always refer to your local regulatory authority for the most current information.
? Did You Know?
Nisin occurs naturally in Produced by Lactococcus lactis bacteria during fermentation. Many people consume it daily without realizing it's also a listed food additive.
Nisin is produced through fermentation — the same biological process used to make bread, beer, and yogurt.
Nisin isn't just a food additive — it's also used in medicine.
Detailed Regulatory Assessment
European Union (EFSA)
Approved for use in various food categories including cheese, canned vegetables, and dairy desserts
Official EFSA LinkUnited States (FDA)
Affirmed as GRAS for use in pasteurized cheese spreads and other foods
Japan (MHLW)
Approved as existing food additive (natural origin)
Acceptable Daily Intake (ADI)
International Standard (JECFA)
mg/kg body weight per day
European Standard (EFSA)
Everyday Perspective
For a 60kg adult, this limit is roughly equivalent to consuming:
Natural Occurrence
NATURAL preservative produced by 'good bacteria' (Lactococcus lactis) during fermentation. A 'bacteriocin' - literally a peptide made by bacteria to kill other bacteria. Works like a natural antibiotic but is NOT considered an antibiotic. Discovered in 1928 (same era as penicillin!) at a Nissan cheese factory in England. Named after the Latin 'Nisus'. Breaks down in stomach acid, so no impact on gut bacteria. One of the safest preservatives - made by the same bacteria used to make cheese.
Manufacturing
Produced by fermentation using Lactococcus lactis bacteria, then purified and concentrated for use as a food preservative.
Applications Beyond Food
Research into antimicrobial applications